Cluster of Differentiation 38



Cluster of Differentiation 38 (CD38), known also as ADP-ribosyl cyclase 1 (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca++ signaling. The images at the left and at the right correspond to one representative CD38, i.e. the crystal structure of bovine Cluster of Differentiation 38 (3gc6).

CD38
3gc6 – bCD38 - bovine

3gh3, 3ghh – bCD38 residues 32-278

2eg9 - CD38 enzymatic domain (mutant) – mouse

2ef1 - hCD38 enzymatic domain – human

1yh3 - hCD38 enzymatic domain (mutant)

1zvm - hCD38 (mutant)

CD38+ligand
3i9m, 3i9n – hCD38 enzymatic domain+ADPR analog 3f6y – hCD38 enzymatic domain+Ca++

3dzf - hCD38 enzymatic domain+intermediate

3dzg - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex

3dzh - hCD38 enzymatic domain (mutant)+GTP

3dzi - hCD38 enzymatic domain (mutant)+intermediate/GTP complex

3dzj, 3dzk - hCD38 enzymatic domain (mutant)+NMN complex

2pgj, 2pgl - hCD38 enzymatic domain (mutant)+substrate analog

2o3t - hCD38 enzymatic domain (mutant)+cGDPR

2o3u - hCD38 enzymatic domain (mutant)+NGD

2o3q, 2o3r, 2o3s - hCD38 enzymatic domain (mutant)+cADPR

2i65 – hCD38+NAD

2i66 - hCD38 (mutant)+GDP intermediate

2i67 - hCD38 (mutant)+ADPR

2hct - hCD38 enzymatic domain (mutant)+NMN